Agency for Healthcare Research and Quality
- Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional) multiple due dates until 8/1/2026
The objective of this NOFO is to improve the quality of healthcare services delivery at the point of care through integration of digital healthcare solutions. This NOFO aims to support phased exploratory and developmental research projects that test promising digital healthcare interventions used at the point of care and intended to improve the quality of healthcare services delivery. - Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety (R18) multiple due dates until 5/26/2027
The purpose of this NOFO is to invite grant applications that support healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used.
Department of Defense
- DARPA Biological Technologies Office (BTO) Broad Agency Announcement rolling until 9/10/2025
Topics of interest related to AI/ML include biological data generation, assessment, and incorporation into the biological foundation models, developing ML and AI-enabled technologies to improve the accuracy, precision and efficiency of warfighter decision-making, and the development of visual testbeds, digital twins, and/or synthetic data. - DARPA Information Innovation Office (I2O) Broad Agency Announcement rolling until 10/29/25
The Information Innovation Office (I2O) creates groundbreaking science and develops transformational capabilities in the informational and computational spheres to surprise adversaries and maintain enduring advantages for national security. I2O programs address elements of four key thrust areas: Proficient artificial intelligence (AI); Resilient, adaptable, and secure systems; Advantage in cyber operations; and Confidence in the information domain. - Geospatial Intelligence Processing and Exploitation (GeoPEX) Broad Agency Announcement rolling until 9/30/2026
The Air Force Research Laboratory seeks white papers for research, development, integration, test and evaluation of technologies/techniques to provide geospatial intelligence. - DEVCOM Army Research Laboratory Broad Agency Announcement for Foundational Research rolling until 11/20/2027
Current research topics include AI Model Optimization for Real-Time, Scalable Data Analytics, Artificial Intelligence and Machine Learning with Extremely Sparse Data, Artificial Intelligence and Machine Learning-Enabling Technologies for Expeditionary Maneuver and Air/Ground Reconnaissance, Artificial Intelligence and Machine Learning: Managing Massive Data Sets. - DEVCOM Analysis Center Broad Agency Announcement For Applied Research rolling until 1/4/2028
Current research topics include Human-Systems Integration Analysis – Artificial Intelligence/Machine Learning for Army System Development and Assessment, Methodologies and Techniques to Analyze Assistive Automation (AA) & Artificial Intelligence (AI) enabled systems, Network Vulnerability and Effects Assessment Methodology (N-VEAM). - Artificial Intelligence Integration Center (AI2C) Broad Agency Announcement rolling until 5/31/2029
The Army Artificial Intelligence Integration Center (AI2C) is seeking artificial intelligence research and development whitepapers and proposals in support of new technologies and translational research-based approaches that support the identification, alignment, and exploitation of basic, applied, and advanced research and technology.
Department of Energy
- FY 2025 Continuation of Solicitation for the Office of Science Financial Assistance Program due per solicitation
The Office of Science indicates interest in AI/ML proposals across all of its programs. Some programs use the open call to solicit research proposals, while other programs areas issue targeted funding solicitations for research.
National Institutes of Health
- NOSI: Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research due per solicitation
The purpose of this Notice of Special Interest (NOSI) is to encourage grant applications to support the evaluation of the utility and validity of digital health and artificial intelligence/machine learning (AI/ML) tools and technologies in biomedical and behavioral research. - NOSI: Explainable Artificial Intelligence for Decoding and Modulating Neural Circuit Activity Linked to Behavior due per solicitation
The eXplainable Artificial Intelligence (XAI) framework aims to provide strong predictive value along with a mechanistic understanding of AI solutions by combining machine learning techniques with effective explanatory techniques. This Notice of Special Interest (NOSI) solicits applications in the area of XAI applied to neuroscientific questions of encoding, decoding, and modulation of neural circuits linked to behavior. - NOSI: Advancing Data Science Research in HIV: Responding to a Dynamic, Complex, and Evolving HIV Epidemic with Artificial Intelligence/Machine Learning due per solicitation
This NOSI seeks to advance data science research in HIV by encouraging the generation of cutting-edge synthetic datasets, artificial intelligence, and machine learning approaches to expand our capacity to address the dynamic, complex, and evolving HIV epidemic. - NOSI: Application of Artificial Intelligence in Treatment Development for Substance Use Disorders due per solicitation
The purpose of this Notice of Special Interest (NOSI) is to elicit projects that would leverage the power of generative AI/ML and predictive models to accelerate medication discovery and development for treatment of SUDs while reducing the risk of failure. - NOSI: AI/ML in Pre-Clinical Drug Development for Psychiatric Disorders due per solicitation
The purpose of this Notice of Special Interest (NOSI) is to encourage the use of artificial intelligence (AI)/ machine learning (ML) methods to accelerate any of the steps of preclinical Drug Discovery (DD): target identification, lead identification, and lead optimization.
National Science Foundation
- Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) due 5/5/2025
Supports interdisciplinary research projects that explore the mathematical and engineering foundations behind the development and use of digital twins in biomedical and healthcare applications. - ACED: Accelerating Computing-Enabled Scientific Discovery (ACED) due 5/5/2025
Supports interdisciplinary collaborative research to explore new computational technologies and accelerate scientific discovery. - Science of Learning and Augmented Intelligence due 8/6/2025
Supports research to develop fundamental knowledge about principles, processes and mechanisms of learning and about augmented intelligence — how human cognitive function can be augmented through interactions with others and technology. - Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) due 10/3/2025
Supports the development of transformative advances in computer and information science, engineering, mathematics, statistics, behavioral and cognitive research to address pressing questions in the biomedical and public health communities. - Cybersecurity Innovation for Cyberinfrastructure (CICI) due 1/21/2026
Supports the development and integration of advanced cybersecurity solutions to improve scientific cyberinfrastructure's security, resilience and usability, enabling secure and reproducible data-driven discoveries across various research fields. - Artificial Intelligence, Formal Methods, and Mathematical Reasoning (AIMing) due 2/5/2026
Supports research at the interface of innovative computational and AI technologies and new strategies/technologies in mathematical reasoning to guide and enhance research in the mathematical sciences, formal methods and AI. - Collaborations in Artificial Intelligence and Geosciences (CAIG) due 2/6/2026
Supports interdisciplinary projects that leverage AI to address geoscience challenges, fostering collaboration between experts to advance Earth system understanding and workforce development. - Dear Colleague Letter: Advancing Research at the intersection of Biology and Artificial Intelligence (AI)/Machine Learning (ML) due per solicitation
BIO encourages the submission of proposals that advance biological research using Artificial Intelligence/Machine Learning (AI/ML) or AI/ML methods using biological data and systems. - Foundational Research in Robotics (FRR) due per solicitation
Supports research on robotic systems that exhibit significant levels of both computational capability and physical complexity. For the purposes of this program, a robot is defined as intelligence embodied in an engineered construct, with the ability to process information, sense, plan, and move within or substantially alter its working environment. - Cyber-Physical Systems (CPS) due per solicitation
Supports research on engineered systems with a seamless integration of cyber and physical components, such as computation, control, networking, learning, autonomy, security, privacy and verification, for a range of application domains. - Robust Intelligence (RI) due per solicitation
Supports computational research in artificial intelligence, machine learning, computer vision, human language technologies and computational neuroscience. - Human-Centered Computing (HCC) due per solicitation
Supports interdisciplinary research in human-computer interaction to design technologies that amplify human capabilities and to study how human, technical and contextual aspects of computing and communication systems shape their benefits, effects and risks. - Networking Technology and Systems (NeTS) due per solicitation
Seeks fundamental scientific understanding of and advances in large-scale, complex, heterogeneous communications networks, including, but not limited to, internet of things (IoT), home, edge, enterprise, data center, cloud, and Internet or Internet-scale networks, and in the wireless areas of cellular, vehicular, mesh, sensor, body area, satellite, and underwater networks. - Software and Hardware Foundations (SHF) due per solicitation
Supports research on the design, evaluation and operation of computer hardware and software.